TOMSK, Sep 9 – RIA
Tomsk. Neuroscientists of Tomsk State (TSU) and
Siberian State Medical (SSMU) universities plan to introduce a new approach to
study brain damage in patients with Parkinson's disease; scientists will assess
state of myelin in brain according to MRI data processed with the help of a
special mathematical model, the press service of TSU reports on Monday.
It is specified that myelin is
the main substance of covers of nerve fibrils on which the correct signaling
between brain neurons depends. The unique noninvasive way developed under
supervision of professor of the University of Washington and TSU Vasily Yarnykh
allows to estimate a damage rate of nervous covers to neurobiologists.
"The essence of the
method is a special mathematical processing of MRI data, which allows to build
myelin maps and to quantify it. This method opens up new opportunities in
obtaining additional diagnostic information about patients with diseases in
which demyelination occurs,"– the press service quotes the Laboratory of
Neuroscience of TSU Marina Khodanovich.
Neurobiologists of TSU use the
new tool for assessment of pathological changes of covers of nerve fibrils at
the people having Parkinson's disease for the first time in world clinical
practice in 2019. Specialists of SSMU (Tomsk) and Scientific-Research Institute
of Physiology and Basic Medicine of SB RAS (Novosibirsk), who will make
selection of patients, will participate in a joint research, it is noted in the
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MRI-researches will be carried
out on the basis of Scientific Research Institute of Oncology of the Tomsk
National Research Medical Center and Scientific-Research Institute of
Physiology and Basic Medicine of SB RAS. At the following stage neurobiologists
will make processing of MRI-images and will receive MPF maps of a myelin of a
brain which allow to estimate quantity of a myelin and a condition of covers of
nerves at having Parkinson's disease.
"Researchers expect to
receive additional information important for clarifying a diagnosis, choosing
treatment tactics and understanding the development of pathological processes
that lead to the complete loss of human capacity," – it is said in the
"The method (of the Tomsk
neurophysiologists) already takes root on the basis of several Russian clinics
and medical centers. The MRI-research of the patients who had a stroke is
conducted in cooperation with clinical physicians of the Pirogov Russian
National Research Medical University. Scientists trace a condition of nervous
covers of a brain of patients according to MPF cards. Such monitoring was
impossible before," – it is added in the message.
Earlier scientists already
tested a new noninvasive method of researches. Scientists analyzed change of a
myelin at rats who had a stroke in dynamics (every other day, for the third and
tenth day) and obtained data on how there is a death of neurons, growth of
inflammation and destruction of a myelin. Results of post-mortal histologic
researches validated conclusions of scientists, the press service notes.