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5:25 PM  October 20, 2020

TSU scientists created a tool to track young neurons in the brain

© сайт Томского госуниверситетаTSU scientists created a tool to track young neurons in the brain

TOMSK, Oct 20 – RIA Tomsk. Scientists of TSU together with colleagues from Belgium and the United States created a tool to track young neurons in the brain; the development cannot be applied to humans, but it allows to evaluate in laboratory animals how the brain recovers after a stroke, this will help create new methods of treating people, the university's website said.

It is specified that the tool was created with the support of the Russian Science Foundation (RSF). With reference to the head of the laboratory of neurobiology of the Biological Institute of Tomsk State University, Marina Khodanovich, it is explained that after a stroke, young neurons are produced in special zones of neurogenesis: they migrate to the affected area to replace the dead. Previously, there were no methods to track these cells in a living brain.

"Neuroscientists created a non-invasive tool that can track the movement of young neurons. For this, scientists mark new brain cells with a special marker that can be seen on MRI. Viral vectors – inactivated viruses that can easily enter the cell, act as "couriers for delivery", – says the message.

According to the press service, in addition to TSU scientists, specialists from Katholieke Universiteit Leuven (Belgium) – Irina Thiry and Veronique Daniels are participating in the project. The researchers tested the created tool on rats: they simulated ischemic cerebral stroke in laboratory animals, introduced a genetic tag and tracked the process of neurogenesis.

"The brains of rats were scanned in Novosibirsk on the most powerful high-field magnetic resonance imager in Russia, designed for research on small laboratory animals. Within the framework of the experiment the condition of 40 stroke survivors animals was assessed. The experiment showed the effectiveness of the created instrument", – the report said.

According to Khodanovich, the method cannot be used on humans, since it requires an increase in the ferritin content, and this affects cell metabolism. But the new approach makes it possible to trace in animals how the brain recovers from stroke, injury and other diseases, which will help create new therapies and predict brain recovery after severe disorders.

Наверх
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