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4:54 PM  October 6, 2021

TSU scientists and colleagues create genomic fighting cancer methods

© сайт Томского государственного университетаTSU scientists and colleagues create genomic fighting cancer methods

TOMSK, Oct 6 – RIA Tomsk. Scientists of Tomsk State University (TSU), together with colleagues, will create new-generation genetic technologies to predict the course and effectiveness of therapy for tumors of the breast, colon, lung, larynx, prostate, ovary and cervix, according to the university's website on Wednesday.

Earlier it was reported that Tomsk doctors will develop genetic technologies for blocking metastases in cancer. For the implementation of the project, Siberian State University (SSMU) received a grant from the Ministry of Science and Higher Education of the Russian Federation in the amount of more than 260 million rubles. The grant became one of the largest in the history of SSMU and was obtained thanks to the unification of competencies within the framework of the Big University.

"The project manager is Professor, Head of the Department of Innate Immunity and Immunological Tolerance of Heidelberg University (Germany), an employee of SSMU and Tomsk State University Julia Kzhyshkowska. The project will create new technologies for epigenomic editing of intratumoral innate immunity to prevent the process of metastasis formation... Along with this, scientists will develop approaches for targeted effects on systemic immunity and programming it to block tumor progression," the report explains.

It is added that the project will involve participants of an interdisciplinary consortium initiated by TSU, including employees of the TSU translational cell and molecular biomedicine laboratory, which is headed by Kzhyshkowska, and the Faculty of Chemistry of TSU.

"In most cases, the death of (oncological) patients is not caused by the malignant neoplasm itself, but by the process of metastasis – the appearance of secondary foci of the tumor. Our task is to develop new generation genetic technologies for the prognosis of course, effectiveness of therapy for tumors of the breast, colon, lung, larynx, prostate, ovary and cervix," the report quotes Kzhyshkowska.

© предоставлено пресс-службой ТГУ
Julia Kzhyshkowska
It is specified that scientists will conduct studies that will become the basis for the creation of prototypes of gene therapy drugs with directed effects on tumor and immune cells that prevent the transition of micrometastases to macrometastases.

Researchers have already created a great scientific background: unique models of tumor-associated macrophages have been developed, new functional biomarkers of their pathological activity have been identified, the role of macrophages in the response to chemotherapy and in the development of tumor chemoresistency has been established, the first steps have been taken to create genetically engineered therapeutic vectors based on alphaviruses to affect the tumor microenvironment.

Наверх
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