TOMSK, Nov 24 – RIA Tomsk, Evgenia Plankina. Tomsk and Biysk scientists develop the anesthetizing tablets based on hexaazaisowurtzitane – substance, which is a component of rocket fuel and explosive, the press service of the innovative organizations of the Tomsk region reports on Thursday.
According to the press service, the Biysk Institute for Problems of Chemical and Energetic Technologies of the Siberian Branch of the Russian Academy of Science and the Tomsk research and production center Chemical Technologies and Scientific Research Institute of Pharmacology are engaged in development of the medicine. Components of explosives are produced in Biysk, Tomsk residents are engaged in the pharmacological part of the development.
It is noted that scientists have received several derivatives basend on hexaazaisowurtzitane and with the revealed pharmacological activity, and part of them shown the expressed analgetic properties. Animal testing defined the most active agents, which can become a basis of analgesic medicine.
"The medicine based on hexaazaisowurtzitane possesses a new mechanism of action, which is connected with blockade of the cellular channels, involved in carrying out pain. Chemical compound blocks them therefore pain. <…> It influences opioid receptors, which don't form dependence and don't cause accustoming", – the head of the working group Olga Vaizova is quoted in the message.
It is noted, the technology of synthesis of substance is created today and substances are defined, which will be a part of a tablet besides the main bond. The scientists should investigate substance's toxicity and to estimate its analgetic properties. The drug will be ready to clinical tests in two years.
According to Vaizova, it is difficult to say, what types of pain will be possible to ease by the new analgetic. The first tests on animals showed that bond reduces the pain caused by thermal and chemical irritants. According to her, it is not the first medicine, which is synthesized from explosive components. The most known such drug is nitroglycerinum.