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18 июля 2019  |  
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6:00 PM  June 19, 2019

TSU and Stockholm scientists get grant for project with "elderly" mice

© с сайта ТГУTSU and Stockholm scientists get grant for project with elderly mice

TOMSK, Jun 20 – RIA Tomsk. Scientists of Tomsk State University (TSU) and one of Europe’s largest medical universities – Karolinska Institute (Sweden), received a grant of the Russian Science Foundation to study metabolic disorders that lead to the development of type 2 diabetes. They will conduct experiments with mice, whose age corresponds to 50-80 years of human life.

How "elderly" mice can help science, RIA Tomsk was told by Leonid Kapilevich, the head of the department of the TSU Faculty of Physical Education.

Find the "switch"

"The project’s scientific supervisor – is Alexander V. Chibalin from Karolinska Institute in Stockholm, a renowned specialist in skeletal muscle physiology. Together with him we received a three-year grant with an annual funding of 6 million rubles. All studies will be conducted at the TSU base", – says Kapilevich.

According to the TSU website, out of 100% of patients with diabetes almost 90% are have the second type. In this form, the patient produces insulin, but the body cannot use it effectively. Diabetes of the second type develops slowly and imperceptibly, many people are diagnosed only after the onset of complications.

Tomsk scientists with the colleague from Sweden intend to find a "switch" that increases or decreases the sensitivity of cells to insulin, including at physical exercise. For this, physiologists will model this disease in mice. Such an experiment will be conducted for the first time in rodents, whose age corresponds to 50-80 years of human life.

"Scientists rarely work with mice of this age, most often mice at the age of one or two months help science", – comments Kapilevich. – We need mice at the age of eight to ten months. They are raised for us in the vivarium of the Research Institute of Pharmacology. By September, we will get mice and start research".

Schedule training

Kapilevich explains that this project was preceded by another study: in 2018, scientists modeled diabetes mellitus in laboratory mice and created a kind of treadmill for daily rodents training. As a result, scientists found that the group that ran in the morning had a lower glucose level, and in mice who were training in the evening, – insulin "fell" faster.

"Exercise helps with diabetes mellitus – this is a well-known fact. The main task – is to understand what is happening at the molecular level. It is unknown to scientists. It is necessary to find out how muscles change, how ability of the heart is restored and other processes affecting quality of life", – the TSU scientist said.

© видео предоставлено пресс-службой ТГУ
According to the press service of the university, during the project will be also examined the relationship between metabolic syndrome and sarcopenia. The obtained data will help to develop new approaches to the treatment of these ailments and to improve the quality of life of people of pre-retirement and elderly age.

As it is specified on the website of the university, at present, the treatment of type 2 diabetes mellitus is carried out mainly due to a strict diet, physical activity and some drugs that lower sugar. Fundamental data, to which research of TSU scientists is aimed, can be used to create fundamentally new drugs that stimulate the launch of the natural utilization of sugar in the patient's body.


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