© с сайта Томского госуниверситета
TOMSK, Apr 24 – RIA Tomsk. Scientists of Tomsk State University (TSU) and
colleagues from Tomsk National Research Medical Center (TMNRC) study the
behavior of "devourer" cells which can suppress or develop cancerous
tumors and myocardial infarction; results of the study will allow to create new
approaches to the treatment, the press service of the university said on
Tuesday.
Earlier it was reported that scientists from Tomsk State University and
TMNRC together with colleagues from Germany and Latvia are creating a new way
of oncological diseases treating, the essence of which is in the impact on the
microenvironment of tumor cells. One of the key elements of regulation are
macrophages, which can both inhibit the growth of the tumor, and vice versa
help the tumor grow.
The press service of the university said that the
"devourers"-cells (macrophages) can have both a positive and negative
impact on the development of tumors. In addition, "bad" macrophages
were found in the myocardium of patients for whom the infarction ended fatal.
"In order to learn how to block the activity of "bad"
macrophages, it is necessary to find out, under the influence of what factors
their transformation takes place ... In the framework of the project, they will
conduct a series of studies involving patients suffering from breast cancer.
The scientists will compare the phenotypes of macrophages in women with
different course of the disease – with metastases and without them, with
relapses and without them, and with other features", – is said in the
report.
© с сайта Томского госуниверситета
It is also added that scientists also plan to study the effect of
preoperative chemotherapy on the functions and phenotype of monocytes (which
differentiate into macrophages) in patients with lung cancer and post-infarction.
They will reveal their relationship with the severity of the course of the
disease and the body's response to "chemistry." A separate block of
the project will be devoted to the study of the role of "bad"
macrophages when bone implants are rejected.
"Understanding the laws under which there "live"
pro-tumor macrophages and their precursors – monocytes, will help to develop a
personalized approach to prescribing of chemotherapy and identify targets that
need to be influenced to defeat cancer", – the press service adds.