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5:57 PM  December 21, 2021

TSU scientists' project to make medicines more effective

© сайт Томского государственного университетаTSU scientists' project to make medicines more effective

TOMSK, Dec 21 – RIA Tomsk. Scientists of Tomsk State University (TSU) are developing new forms of drugs used, among others, to treat coronary heart disease; the goal of the research is to increase several times the ability of drugs to "reach" the site of their action in the human body, the university's website reported on Tuesday.

It is specified that the project is supported by the Russian Science Foundation (RSF). The project involves scientists of TSU Faculty of Chemistry and Goldberg Research Institute of Pharmacology and Regenerative Medicine. The objects of the study are substances from the group of phenolic antioxidants - isobornylphenol, ionol, tocopherol, quercetin and others, which have pronounced antioxidant, cardio- and neuroprotective properties.

"A number of them are used to treat coronary heart disease. They can increase life expectancy after acute myocardial infarction. There is data showing that when taken orally, the studied substances have low bioavailability, i.e. no more than 10% is absorbed in the gastrointestinal tract," project manager Vyacheslav Yanovsky is quoted in the report.

The researchers aim is to increase bioavailability of capsules and tablets from 10-15% to 50%. This will not only improve treatment efficacy but also reduce the number of side effects, the report said.

© РИА Томск. Павел Стефанский
"The task being tackled by TSU chemists under the Russian Science Foundation project is to create new dosage forms in the form of micro- and nanoemulsions. The extremely small particle size of the studied substances will allow the drugs to overcome the barrier in the form of a cell membrane and get into the systemic blood circulation much faster," the university's press service said.

Scientists of the Goldberg Research Institute of Pharmacology and Regenerative Medicine will assess how the absorption of active pharmaceutical changes depending on the emulsion formulation, particle size, etc., study the distribution of the investigated substances in organs and tissues, examine the impact of new dosage forms on pharmacokinetic parameters. All experiments will be performed on laboratory animals from the institute's vivarium.

Наверх
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